Diabetes Clinical Research

Clinical research is patient-oriented research. Research may be conducted in human volunteers or on samples from humans. NIH-funded studies are carefully designed to answer specific medical questions while protecting participants' safety. Well conducted clinical trials are the fastest and safest way to find improved treatments and preventions for diseases. Clinical trials or interventional trials determine whether experimental preventions, treatments, or new ways of using known therapies are safe and effective under controlled conditions. Observational or natural history studies examine health issues and disease development in groups of people or populations. The National Library at Medicine explains more about clinical research in Understanding Clinical Trials.

• Recruiting
• Completed
• Ongoing - No Longer Recruiting
• Follow-up Studies
• Consortia, Registries, Repositories

• The Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD)
  NIDDK is co-funding a study to test best ways to lower risk of heart disease and stroke in adults with type 2 diabetes.
  
  
• Bypass Angioplasty Revascularization Investigation (BARI) 2 Diabetes
  | www.bari2d.org/
  This study, co-funded by NIDDK, aims to determine the best therapies for people with type 2 diabetes and heart disease.
  
  
• Diabetes Research in Children Network (DirecNet)
  | http://public.direc.net/
  This clinical center network is researching the potential use of glucose monitoring technology and its impact on the management of type 1 diabetes in children.
  
  
• Immune Tolerance Network (ITN)
  | www.immunetolerance.org/index.shtml
  NIDDK co-funds this international consortium dedicated to evaluating new treatments for autoimmune diseases, asthma, and allergic diseases, and to preventing rejection of transplanted kidneys and pancreatic islets.
  
  
• Islet Transplantation Trials for Type 1 Diabetes
  Various research centers are performing islet transplantations in a small number of adults with type 1 diabetes.
  
  
• SEARCH for Diabetes in Youth Study
  | www.searchfordiabetes.org/
  This study, co-funded by NIDDK, will determine the prevalence of diabetes in children in six areas of the U.S. and help clarify trends in the development of diabetes in youth.
  
  
• TODAY Trial
  The TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) study, which seeks to identify the best treatment of type 2 diabetes in children and teens, has begun in 12 medical centers and affiliated sites around the country.
  
  
• Type 1 Diabetes Special Funding Studies
  Several studies are recruiting type 1 diabetes patients (including new-onset patients) and their family members. These studies are supported by a special type 1 diabetes research program.
  
  
• Type 1 Diabetes TrialNet
  Type 1 Diabetes TrialNet is a network of clinical centers, experts in diabetes and immunology, and specialized laboratories dedicated to testing new approaches to understanding and preventing type 1 diabetes. This clinical research program seeks to prevent type 1 diabetes in high-risk people and to preserve insulin production in those newly diagnosed. Patient recruitment for upcoming trials is planned for the beginning of 2004.
  
  
• ClinicalTrials.gov
  For other studies in diabetes, search this comprehensive database.
  
  

• Look AHEAD: Action for Health in Diabetes
  Look AHEAD (Action For Health in Diabetes) is a randomized clinical trial in people with type 2 diabetes that examines the effects of weight loss over the long term through decreased caloric intake and exercise.
  
  
• Diabetes Prevention Program Outcomes Study (DPPOS)
  DPPOS is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of the Diabetes Prevention Program (DPP).
  
  
• Epidemiology of Diabetes Interventions and Complications (EDIC) Study
  EDIC is studying the long-term complications of type 1 diabetes in participants of the Diabetes Control and Complications Trial.
  
  

• Diabetes Control and Complications Trial (DCCT)
  The DCCT is a clinical trial showing that blood glucose levels kept as close to normal as possible slows the onset and progression of eye, kidney, and nerve diseases caused by diabetes. Epidemiology of Diabetes Interventions and Complications (EDIC) Study is a follow -up study of the participants in the DCCT.
  
  
• Diabetes Prevention Trial--Type 1
  Both trials of the DPT-1--the low-dose insulin injection trial in people at high risk for type 1 diabetes and the oral insulin trial in people at moderate risk for type 1 diabetes--have ended. Although neither approach was able to prevent the development of type 1 diabetes, researchers in Type 1 Diabetes TrialNet are continuing the search for ways to prevent or slow the autoimmune destruction of beta cells.
  
  
• Diabetes Prevention Program (DPP)
  Diet and exercise dramatically delay type 2 diabetes. Diabetes medication metformin is also effective in cutting risk. Diabetes Prevention Program Outcomes Study (DPPOS) is a follow-up study to the participants enrolled in the DPP study.
  
  

• Diabetes Prevention Program Outcomes Study (DPPOS)
  DPPOS is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of the Diabetes Prevention Program (DPP).
  
  
• Epidemiology of Diabetes Interventions and Complications (EDIC) Study
  EDIC is studying the long-term complications of type 1 diabetes in participants of the Diabetes Control and Complications Trial.
  
  

• Beta Cell Biology Consortium (BCBC)
  The mission of the Beta Cell Biology Consortium (BCBC) is to facilitate interdisciplinary approaches that will advance the understanding of pancreatic islet development and function.
  
  
• Collaborative Islet Transplant Registry
  The CITR expedites progress and promotes the safety of islet transplantation by collecting, analyzing, and communicating data on islet transplants in the U.S. and Canada.
  
  
• Endocrine Pancreas Consortium
  The Endocrine Pancreas Consortium was formed in late 1999 to derive and sequence cDNA libraries enriched for rare transcripts expressed in the mammalian endocrine pancreas.
  
  
• Environmental Determinants of Diabetes in the Young (TEDDY)
  | www.teddystudy.org/
  This consortium is organizing international efforts to identify infectious agents, dietary factors, or other environmental factors that trigger type 1 diabetes in genetically susceptible people.
  
  
• Genetics of Kidneys in Diabetes (GoKinD)
  The purpose of the GoKinD Study is to establish a repository of DNA and clinical information from 1,100 adults with Type 1 diabetes, along with their parents to better understand how genetics contributes to the development of diabetic kidney disease.
  
  
• International Type 1 Diabetes Genetics Consortium
  This consortium is organizing international efforts to identify genes that determine a person's risk of type 1 diabetes.
  
  
• International Type 2 Diabetes Linkage Analysis Consortium
  This consortium is organizing international efforts to combine existing data sets for linkage analysis in an effort to map genes for type 2 diabetes. In addition, the availability of a large number of samples allows for analysis of individual ethnic groups for predominant diabetes susceptibility genes.
  
  
• Islet Cell Resource Centers
  The mission of the Islet Cell Resource Centers (ICRs) is to provide pancreatic islets for basic science studies and clinical trials and to optimize the harvest and shipment of islets while developing tests that characterize the quality and predict the effectiveness of islets transplanted into patients with diabetes mellitus.
  
  
• NIDDK Central Repositories
  The Biosample, Genetics, and Data Repositories have been established to store biosamples and data collected in designated NIDDK-funded clinical studies. The purpose of the NIDDK Central Repositories is to expand the usefulness of these studies by allowing a wider research community to access these materials beyond the end of the study.
  
  
• Type 1 Diabetes Special Funding Program
  Information on research funding opportunities, resources, consortia, and networks supported by the Special Funding Program for Type 1 Diabetes Research.