Epidemiology of Diabetes Interventions and Complications Study (EDIC)
What Is EDIC?
The Epidemiology of Diabetes Interventions and Complications Study (EDIC) is an
observational study examining the risk factors associated with the long-term complications
of type 1 diabetes. The study began in 1994 and follows the 1441 participants previously
enrolled in the Diabetes
Control and Complications Trial (DCCT).
EDIC Background
The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions
and Complications (EDIC) Study is entering its 21st year. From 1983 to 1989, 1441
type 1 diabetic participants were recruited into the DCCT. They were randomly assigned
to 2 treatment groups, intensive and conventional for an average of 6.5 years of
randomized treatment time. The DCCT ended in 1993 after demonstrating conclusively
that intensive treatment (mean HbA1c 7.2%) reduced the development and progression
of diabetic retinopathy, nephropathy and neuropathy, compared to conventional treatment
(mean HbA1c 9.0%).In 1994, 96% of the participants were enrolled in EDIC for regular
observational follow-up of metabolic and complications status, using similar methods
as in the DCCT. Diabetes care is obtained from the EDIC participants' own physicians.
EDIC Objectives
The primary aim of EDIC is to examine the long-term effects of conventional vs.
intensive diabetes treatment received during the DCCT on the subsequent development
and progression of microvascular, neuropathic and cardiovascular complications.
This involves studying the influence of genetic factors and other factors such as
HbA1c, blood pressure, lipid levels, and treatment modalities on the development
and progression of these complications.
EDIC Clinical Centers
EDIC is made up of 28 clinical centers and one data coordinating center funded by
the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
DATA COORDINATING CENTER
THE GEORGE WASHINGTON BIOSTATISTICS CENTER
Rockville, MD
CLINICAL COORDINATING CENTER
CASE WESTERN RESERVE UNIVERSITY
Cleveland, OH
CLINICAL CENTERS
Albert Einstein College
of Medicine
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University of Minnesota
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Case Western Reserve
University
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University of Missouri
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Cornell University Medical Center
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University of New Mexico
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Henry Ford Health System
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University of Pennsylvania
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International Diabetes Center
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University of Pittsburgh
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Joslin Diabetes Center
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University of South Florida
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Massachusetts General Hospital
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University of Tennessee
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Mayo Foundation
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University of Texas
Southwestern University Medical Center
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Medical University of South Carolina
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University of Toronto
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Northwestern University
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University of Washington
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University of California, San Diego
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University of Western Ontario
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University of Iowa
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Vanderbilt University
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University of Maryland School of Medicine
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Washington University, St. Louis
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University of Michigan
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Yale University School of Medicine
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