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Monday, August 11, 2008 |
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| 7:30 – 8:30 a.m. | Registration |
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| 8:30 – 8:45 a.m. | Welcome
Organizing Committee |
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| 8:45 – 10:15 a.m. | Overview |
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| | Why Do Mutations in Ribosomal Proteins Mainly Affect Erythropoiesis?
Harvey Lodish, The Whitehead Institute |
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| | Ribosomal Mutations Cause p53-mediated Dark Skin and Pleiotropic Effects
Kelly McGowan, Stanford University |
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| | Identification of RPS14 as a 5q– Syndrome Gene by RNA Interference Screen
Benjamin Ebert, Broad Institute of MIT and Harvard |
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| 10:15 – 10:30 a.m. | Break |
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| 10:30 – 11:30 a.m. | Structure and Function of the Ribosome |
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| | Molecular Basis of Shwachman Diamond Syndrome
Paul de Figueiredo, Texas A&M University |
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| | Tom Kaufman (Invited), Indiana University |
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| 11:30 – 1:00 p.m. | The Nucleolus and rDNA Transcription |
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| | RPS19 and Diamond Blackfan Anemia
Mohandas Narla, New York Blood Bank |
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| | Pathogenesis of the Erythroid Failure in Diamond Blackfan Anemia
Colin Sieff, Harvard Medical School |
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| 1:00 – 2:00 p.m. | Lunch (on your own) |
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| 2:00 – 4:00 p.m. | Ribosomal Biogenesis |
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| | Beware Imbalance in the Synthesis of Ribosomes
Jonathan R. Warner, Albert Einstein College of Medicine������������������������� |
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| | Physical and Functional Clusters of Ribosome Assembly Factors: Recruiting Strategies and Mechanisms to Regulate Pre-rRNA Processing
John L. Woolford, Carnegie Mellon University |
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| | New Insights into How We Make Ribosomes
Susan J. Baserga, Yale University |
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| | Yeast Models of Diamond Blackfan Anemia and Shwachman Diamond Syndrome Differ in Their Effect on the Synthesis and Function of Ribosomal Subunits
Steven R. Ellis, University of Louisville |
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| 4:00 – 6:00 p.m. | POSTER SESSION |
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Tuesday, August 12, 2008 |
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| 7:30 – 8:30 a.m. | Registration |
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| 8:30 – 11:00 a.m. | Ribosomes and Disease |
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| | Clinical Features of Ribosomal Hematologic Diseases
Blanche Alter, National Cancer Institute, National Institutes of Health |
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| | Shwachman Diamond Syndrome: Clinical and Molecular Features
Akiko Shimamura, University of Washington |
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| | An Alternative rRNA Processing Pathway Generates a Specialized Ribosome That is Used for Nonsense-Mediated Decay
Mark E. Schmitt, SUNY Upstate Medical University |
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| | Shwachman-Diamond Syndrome Mice Display ‘Minute-Like’ Phenotypes with Translational Insufficiency
Johanna Rommens, University of Toronto |
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| | Ribosome Biogenesis and Bone Marrow Failure
Monica Bessler, Washington University |
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| 11:00 – 12:30 p.m. | Summary and Discussion |
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| 12:30 p.m. | Adjournment |