Ribosome Biogenesis in Hemotalogic Diseases

AGENDA



Monday, August 11, 2008


7:30 – 8:30 a.m. Registration
   
8:30 – 8:45 a.m.

Welcome
Organizing Committee


8:45 – 10:15 a.m. Overview

 

Why Do Mutations in Ribosomal Proteins Mainly Affect Erythropoiesis?
Harvey Lodish, The Whitehead Institute

   
 

Ribosomal Mutations Cause p53-mediated Dark Skin and Pleiotropic Effects
Kelly McGowan, Stanford University

   
 

Identification of RPS14 as a 5q– Syndrome Gene by RNA Interference Screen
Benjamin Ebert, Broad Institute of MIT and Harvard

   
10:15 – 10:30 a.m.  Break

10:30 – 11:30 a.m. Structure and Function of the Ribosome

 

Molecular Basis of Shwachman Diamond Syndrome
Paul de Figueiredo, Texas A&M University

   
 

Tom Kaufman (Invited), Indiana University


11:30 – 1:00 p.m. The Nucleolus and rDNA Transcription

 

RPS19 and Diamond Blackfan Anemia
Mohandas Narla, New York Blood Bank

   
 

Pathogenesis of the Erythroid Failure in Diamond Blackfan Anemia
Colin Sieff, Harvard Medical School

   
1:00 2:00 p.m. Lunch (on your own)

2:00 4:00 p.m. Ribosomal Biogenesis

 

Beware Imbalance in the Synthesis of Ribosomes
Jonathan R. Warner, Albert Einstein College of Medicine�������������������������

   
 

Physical and Functional Clusters of Ribosome Assembly Factors:  Recruiting Strategies and Mechanisms to Regulate Pre-rRNA Processing
John L. Woolford, Carnegie Mellon University

   
 

New Insights into How We Make Ribosomes
Susan J. Baserga, Yale University

   
 

Yeast Models of Diamond Blackfan Anemia and Shwachman Diamond Syndrome Differ in Their Effect on the Synthesis and Function of Ribosomal Subunits
Steven R. Ellis, University of Louisville


4:00 – 6:00 p.m. POSTER SESSION


Tuesday, August 12, 2008


7:30 – 8:30 a.m. Registration

8:30 – 11:00 a.m. Ribosomes and Disease

 

Clinical Features of Ribosomal Hematologic Diseases
Blanche Alter, National Cancer Institute, National Institutes of Health

   
 

Shwachman Diamond Syndrome:  Clinical and Molecular Features
Akiko Shimamura, University of Washington

   
 

An Alternative rRNA Processing Pathway Generates a Specialized Ribosome That is Used for Nonsense-Mediated Decay
Mark E. Schmitt, SUNY Upstate Medical University

   
 

Shwachman-Diamond Syndrome Mice Display ‘Minute-Like’ Phenotypes with Translational Insufficiency
Johanna Rommens, University of Toronto

   
 

Ribosome Biogenesis and Bone Marrow Failure
Monica Bessler, Washington University


11:00 – 12:30 p.m.   Summary and Discussion

12:30 p.m. Adjournment


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Director: Griffin P. Rodgers, M.D., M.A.C.P
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