Agenda |
| Print Version (PDF) |
| Thursday, December 11, 2008 |
| 7:00 – 8:00 a.m. | Registration and Continental Breakfast |
| 8:00 – 8:05 a.m. | Welcome
Olivier Blondel, NIDDK |
| 8:05 – 8:55 a.m. | Keynote Address: Transcriptional Control of T-cell Activation and Tolerance
Anjana Rao, Harvard Medical School |
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Session 1: miRNAs and the Immune Response
Chair: Klaus Rajewsky |
| 8:55 – 9:00 a.m. | Introduction
Klaus Rajewsky, Harvard Medical School |
| 9:00 – 9:30 a.m. | Gene Regulation by Transcription Factors and microRNAs
Klaus Rajewsky, Harvard Medical School |
| 9:30 – 10:00 a.m. | MicroRNA-mediated Regulation of T-cell Development Function
Chang-Zheng Chen, Stanford University School of Medicine |
| 10:00 – 10:30 a.m. | Break |
| 10:30 – 11:00 a.m. | MicroRNAs in Normal B Cell Development and Lymphomagenesis
Riccardo Dalla-Favera, Columbia University |
| 11:00 – 11:30 a.m. | Role of microRNAs in the Innate Immune Response
Mark Lindsay, University of Manchester, United Kingdom |
| 11:30 a.m. – 12:00 p.m. | Chromatin Control of Antiviral Response
Alexander Tarakhovsky, The Rockefeller University |
| 12:00 – 1:20 p.m. | Lunch |
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Session 2: Epigenetic Regulation of the Immune Response
Chair: Matthias Merkenschlager |
| 1:20 – 1:30 p.m. | Introduction
Matthias Merkenschlager, Imperial College London, United Kingdom |
| 1:30 – 2:00 p.m. | Cohesins in Gene Regulation and Genome Organization
Matthias Merkenschlager, Imperial College London, United Kingdom |
| 2:00 – 2:30 p.m. | Chromatin Poises miRNA and Protein-coding Genes for Expression
Keji Zhao, National Heart, Lung, and Blood Institute |
| 2:30 – 3:00 p.m. | DNA Methylation Controls FOXP3 Gene Expression
Jochen Huehn, Helmholtz Centre for Infection Research, Germany |
| 3:00 – 3:30 p.m. | Break |
| 3:30 – 4:00 p.m. | Distal Regulatory Elements and Epigenetic Regulation of Cytokine Expression in T Helper Cells
Christopher Wilson, University of Washington School of Medicine |
| 4:00 – 4:30 p.m. | Writers, Readers, and Erasers: Epigenetic Regulation of the Dendritic Cell and Macrophage Phenotype
Steven Kunkel, University of Michigan Medical School |
| 4:30 – 5:00 p.m. | Epigenetic Regulation of Hematopoietic Stem Cell Differentiation
Michele Goodhardt, Institut Universitaire d'Hematologie, Paris |
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| Friday, December 12, 2008 |
| 7:00 – 8:00 a.m. | Registration and Continental Breakfast |
| 8:00 – 8:50 a.m. | Keynote Address: Cytoplasmic Determinants of T-cell Fate
Steven Reiner, University of Pennsylvania |
Session 3: miRNA and Epigenetic Regulations in Autoimmune Diseases
Chair: Diane Mathis |
| 8:50 – 9:00 a.m. | Introduction
Diane Mathis, Joslin Diabetes Center |
| 9:00 – 9:30 a.m. | Genetic and Non-genetic Variability in Aire-mediated Control of Immunological Tolerance
Diane Mathis, Joslin Diabetes Center |
| 9:30 – 10:00 a.m. | Epigenetics of Autoimmunity
Bruce Richardson, University of Michigan |
| 10:00 – 10:30 a.m. | MicroRNAs as Targets of FoxP3 and Regulators of Treg Development and Function
Alexander Rudensky, University of Washington, Seattle |
| 10:30 – 11:00 a.m. | Break |
| 11:00 – 11:30 a.m. | Genome-wide DNA Methylation Analysis in Monozygotic Twins Discordant for Type-1 Diabetes
Vardhman Rakyan, Institute of Cell and Molecular Science, London |
| 11:30 a.m. – 12:00 p.m. | Chemical Biology of Foxp3+ Regulatory T cells (Tregs)
Wayne Hancock, Children’s Hospital of Philadelphia and University of Pennsylvania |
| 12:00 – 12:30 p.m. | Regulation of Thymocyte Differentiation by HDAC7
Eric Verdin, University of California at San Francisco |
| 12:30 – 1:40 p.m. | Lunch |
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Session 4: Emerging Therapeutic Strategies in Autoimmune Diseases
Chair: Judy Lieberman |
| 1:40 – 1:45 p.m. | Introduction
Judy Lieberman, Immune Disease Institute, Harvard Medical School |
| 1:45 – 2:15 p.m. | Antibody Fragment-mediated Delivery of siRNA Complexes in Specific Immune Compartments
Judy Lieberman, Immune Disease Institute, Harvard Medical School |
| 2:15 – 2:45 p.m. | Immune Targeting Nanoparticles Containing siRNAs to Curtail Inflammatory Bowel Diseases
Dan Peer, Tel Aviv University, Israel |
| 2:45 – 3:15 p.m. | Oligonucleotide-targeted Dendritic Cells in Autoimmunity
Nick Giannoukakis, Diabetes Institute, University of Pittsburgh |
| 3:15 – 3:30 p.m. | Break |
| 3:30 – 4:00 p.m. | Folate-mediated Targeting of Drugs and siRNAs to Activated Macrophages In Vivo
Philip Low, Purdue University |
| 4:00 – 4:30 p.m. | Amphoteric Liposomes for Targeted Delivery of RNAi in Inflammatory Diseases
Steffen Panzner, novosom AG, Halle, Germany |
| 4:30 p.m. | Wrap-up and Adjournment |
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